Matrixyl-4® Pur Collagen Peptide Serum
Sku: 5051

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Super smooth wrinkle-free skin, super happy resting face

Hyper Concentrated Signalling Protein Peptides to reduce wrinkles and refresh the skin

Unique serum formula that combines all 4 Matrixyl peptide ingredients in one formula for maximum skin benefits.  

The formula is a rich collagen peptide concentrate incorporating all 4 forms of the Matrixyl technology for a powerful anti-wrinkle concentrate like no other.  Matrixyl has been considered the absolute gold standard to support the dermal matrix, reduce wrinkles, promote cell turnover, plump skin, achieve younger and smoother looking skin since its inception in 1998, and continues to hold its top position for real results.

  • Super concentrated blend: Exclusive to ISOMERS Skincare
  • Matrixyl combined total concentration 20%  
  • Anti-wrinkle, smoother more radiant skin
  • Anti Gravity to uplift mouth corners - happier resting face
  • Helps better define facial contours 
  • Helps boost skin recovery to smooth out expression faster - reconnect; helps boost skin memory
  • Helps the appearance of more lifted, contoured, and toned skin posture - vertical lines, marionette lines, and weightiness are diminished and the face has a happier uplifted contour.


Formulated with 4 forms of matrixyl signaling protein peptides:

  1. Matrixyl - (Palmitoyl Pentapeptide) - helps support new collagen, elastin, and hyaluronic acid which aids in refilling wrinkles naturally from within the skin.
  2. Matrixyl 3000 - (Palmitoyl Tetrapeptide) will do this as well and it also inhibits and reverses glycation damage. This added benefit can make this a better choice as a skincare product for some people.
  3. Matrixyl Synthe’6 - deoxygenated lipopeptide that helps support 6 major ingredients in the skin’s matrix and dermal-epidermal junction (collagen I, III, IV, fibronectin, hyaluronic acid). The result is an inside out wrinkle smoothing and correction.
  4. Matrixyl Morphomics - (N-Prolyl Palmitoyl Tripeptide-56 Acetate) Matrixyl Morphomics (N-Prolyl Palmitoyl Tripeptide-56 Acetate) supports dermal morphology by the structural integrity and connectivity between fibroblasts, nucleus, and ECM – The result is a better and stronger reduction of the appearance of vertical lines (frown lines, marionette lines, naso-genian fold) and also crow’s feet after 6 weeks, for a happier expression. With continued use, one will experience more lifted happier facial expressions and less pronounced and visible vertical lines.


Skin concerns: sad resting face - sometimes referred to as resting bitch face.  To indicate a displeasing resting expression caused by sagging skin, deep lines, and pull of time and gravity on the skin.  Deep creases, wrinkles, enlarged pores, slackened skin, deeper vertical marionette lines, heavier frown, and mouth lines. 

About the Science:

  • ISOMERS has been formulating with Matrixyl® for over 2 decades! 
  • Matrixyl has been considered the absolute gold standard to achieve a younger and smoother looking skin since its inception in 1998 and continues to be essential in results-based skincare formulations. 
  • Matrixyl peptides work by stimulating collagen synthesis which is needed to reduce wrinkles and fine lines, especially on the facial area. Each one of the 4 Matrixyl peptides works well in their respective areas and in different areas of the aging process.  However, the real power comes forward when these ingredients are combined and their benefits amplify.  It is when they work together, their individual effectiveness is increased.  

Aqua/Water/Eau, Glycerin, Sodium Hyaluronate, N-Prolyl Palmitoyl Tripeptide-56 Acetate, Palmitoyl Tripeptide-38, Palmitoyl Pentapeptide-4, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Allantoin, Hydroxypropyl Cyclodextrin, Pentylene Glycol, Caprylyl Glycol, Butylene Glycol, Hydroxyacetophenone, Carbomer, Polysorbate 20.

Apply 3-5 drops of serum over the entire face area including the jawline, décolleté, and eye contour.  For best results:  use on clean skin twice a day and follow with a moisturizer from ISOMERS® Skin Care.  As part of an anti-aging program, this may be repeated 2-4 times per year.

 We've received some questions about the use of the Matrixyl-4 Pur Collagen Peptide Serum.

1. You can use this once or twice a day, as part of your skincare routine. If you have deep wrinkles and/or vertical lines then twice a day is optimal. If you have younger or better skin, use once a day.

2. It can be used with any Isomers serums and creams.

3. You do not need to use the Matrixyl Advanced Wrinkle Defense Serum at the same time you're using Matrixyl-4.

4. The Matrixyl-4 is a booster serum. Use until the bottom of the bottle and then take a break. You can maintain your results with Matrixyl Advanced Wrinkle Defense serum and use the Matrixyl-4 Serum 2-4 times per year.

Matrixyl-4 Pur Collagen Peptide Serum - BA1


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